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The Shiels Laboratory

Bianka Grunow

Bianka Grunow

Contact details

E: bianka.grunow@manchester.ac.uk

 

Biography

  • 2014 – onwards: Postdoctoral Research Fellow, University of Greifswald (Germany)
  • 2013 – onwards: visiting scientist, University of Manchester
  • 2011-2012: Postdoctoral Research Fellow, Fraunhofer Research Institution for Marine Biotechnology (Germany)
  • 2008-2011 PhD, Fraunhofer Research Institution for Marine Biotechnology/ University of Lübeck, Germany

My interest are cellular models, especially from fish and their application in biotechnology. My current research project is the development of a cellular model system from fish for the use in pharmacology, because the electrophysiology of fish cardiomyocytes largely resembles that of humans. The last years, the successful establishment of a low-cost 3D in vitro heart model system, which contracts spontaneously over several weeks/ months could be shown from diverse fish species and electrophysiological examinations confirmed the sensitivity to heart channel blockers (ICaL, IKATP, IKr).

Publications

Grunow B., Kirchhoff T., Moritz T. (2016). Stem cell expression and development of trunk musculature of lesser-spotted dogfish (Scyliorhinuscanicula) reveal differences between sharks and teleosts. Acta Zoologica DOI: 10.1111/azo.12167

Grunow B.,Mohamet L., Shiels H.A. (2015). Generating an in vitro 3D cell culture model from zebrafish larvae for heart research.Journal of Experimental Biology 218: 1116-1121 doi: 10.1242/jeb.118224

Grunow B., Kirchhoff T., Lange T., Moritz T., Harzsch S. (2015). Histochemistry on vibratome sections of fish tissue: a comparison of fixation and embedding methods. Aquatic Biology 23(3): 251-263 DOI: 10.3354/ab00624

Grunow B, Böhmert B, Fechner K (2013). Specificity of antibodies established from mammals in rainbow trout (Oncorhynchus mykiss). Journal of Applied Ichthyology 29(5): 1129-1133 DOI: 10.1111/jai.12146

Brandenburger M., Mehnert J., Grunow B. (2013). Pharmacological characterization of spontaneously contracting cardiomyocyte clusters from fish larvae. Journal of Pharmacological and Toxicological Methods 68(1):e11 http://dx.doi.org/10.1016/j.vascn.2013.01.048

Mehnert J., Brandenburger M., Grunow B. (2013). Electrophysiological characterization  of spontaneous contracting cell aggreagtes obtained from rainbow trout larvae with multielectrode array. Cellular Physiology and Biochemistry 32: 1374-1385 DOI:10.1159/000356576)

Grunow B., Schmidt M., Klinger M., Kruse C.(2012). Development of an in vitro cultivated spontaneously long-term contracting 3D heart model system as a robust read-out system. Cell Science and Therapy 3:116. DOI: 10.4172/2157-7013.1000116

Grunow B., Wenzel J., Terlau H., Langner S., Gebert M., Kruse C.(2011). In vitro developed spontaneously contracting cardiomyocytes from rainbow trout as a model system for human heart research. Cellular Physiology and Biochemistry 27: 01-12 doi: 10.1159/000325212.

Grunow B., Noglick S., Kruse C., Gebert M. (2011). Isolation of Cells from Atlantic sturgeon (Acipenseroxyrinchusoxyrinchus) and Optimization of Culture Conditions. Aquatic Biology 14: 67-75 https://doi.org/10.3354/ab00383 

Grunow B., Ciba P., Rakers S., Klinger M., Anders E., Kruse C. (2010). In vitro expansion of autonomously contracting, cardiomyogenic structures from rainbow trout, Oncorhynchus mykiss. Journal of fish biology 76: 427-434 doi: 10.1111/j.1095-8649.2009.02535.x.