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The Shiels Laboratory

James Marchant

James Marchant

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I’m a PhD student at the University of British Columbia, Vancouver, Canada under the supervision of Dr Anthony P. Farrell and hold a bachelors in general biology obtained from the université de Bretagne occidentale, Brest, France, and a Masters in Marine Biology obtained from L’institut universitaire Européen de le mer, Brest France. My research interests lay in physiological responses of the cardiovascular system in ectotherms to global change, more specifically the electrophysiological remodelling of the fish heart in temperature adaptation.

My first Masters project under the supervision of Guy Claireaux and Hélène Ollivier at the IFREMER center, Brest, France and the ORPHY unit of the Université de Bretagne occidentale, involved measuring the participation of the sarcoplasmic reticulum to intracellular calcium influx in ventricular cardiomyocytes in the European sea bass (see publication). My second Masters project which I completed in my current lab at UBC involved measuring electrophysiological changes in the action potential waveform of pacemaker cells in response to temperature acclimation, using micro-electrodes.

In Dr Holly Shiels' lab, my aim is to learn patch clamping techniques which will be useful for my PhD project. The project I have been working on during my visit is the adrenergic response of sodium channels in the rainbow trout cardio myocytes.


Calcium response of KCl-excited populations of ventricular myocytes from the European sea bass (Dicentrarchus labrax): a promising approach to integrate cell-to-cell heterogeneity in studying the cellular basis of fish cardiac performance. 2015. Hélène Ollivier, James Marchant, Nicolas Le Bayon, Arianna Servili & Guy Claireaux. J Comp Physiol B. DOI 10.1007/s00360-015-0924-6