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The Shiels Laboratory


Cardiac Physiology

Survival of nearly all vertebrate animals depends on maintained cardiac function. Environmental changes, such as temperature and oxygen fluctuations, can dramatically affect the ability of the heart to maintain normal function.

To this end, we explore strategies of cardiac adaptation that permit maintenance of heart function in ectotherms living in fluctuating environments. In addition, we investigate the regulation of excitation-contraction coupling in mammalian heart.

Our laboratory has three main specific research areas. For more information click on the following links:

We are grateful to the Wellcome Trust, The Fisheries Society of the British Isles, the Royal Society and the BBSRC for funding the research in our laboratory.